Pandora’s Box is an Active Item that can potentially save a dying run or put the player over the edge on a thriving run. Based on what floor it’s used on, Pandora’s Box will gift the player a number of different things, then disappear.

Note:Pandora’s Box will treat XL floors as if they were the first floor of that area. Also, be careful when using the? Card.Should you use the? Cardin Afterbirth, it will consume both the card and Pandora’s Box without giving you anything. But in Repentance, itwillwork, giving you the item(s) from Pandora’s Box without consuming the Active Item itself.

Screenshot by Pro Game Guides

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